HLSC 3464U Lecture Notes - Lecture 4: Chronic Myelogenous Leukemia, Sickle-Cell Disease, Philadelphia Chromosome
Document Summary
See more variations snv multiple substitutions no limitations on the frequency that is occurring, can result in cancer mutations. Section of the genome is duplicated within the same genome. Number of repeats can vary inherited through family. Greater number of cancer and other diseases. Chromosome is lost or gained within the genome (aneuploid) Polyploidy the actual sets are duplicated. Both important in cancer cells we expect to see these mutations. Short chromosome 22, fragments are exchanged with chromosome 9. A fused gene appears, abl attaches to bcr gene, causing a gene for chronic myeloid leukemia. Cll blood cancer that resides in the bone marrow of the immature myeloid cells. Creates own growth factor independent of other cells survives longer than other cells. Clonal expansion colon is most accessible in cancer research clonal cells that do survive do have an advantage and can outlive the cancer cells involved.
