ANP 1105 Lecture Notes - Lecture 5: Haematopoiesis, Haemophilia A, Von Willebrand Factor

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1105
• Professor: Joanne Savory

Document Summary

Body temp - vasoconstriction + vasodilation of cutaneous blood vessels. Fluid volume - prevent fluid leakage from bloodstream into interstitial space. 8% body weight (guys: 5-6 l; girls: 4-5 l) Only fluid tissue in body (formed elements suspended in plasma) Small diameter but larger than some capillaries. Biconcave disc shape, anucleate, essentially no organelles. Contains protein spectrin: lines internal surface of rbc, able to be deformed + can return to original shape. Small size: concave shape = big sa:v ratio. Hb: 97% of cell volume (not counting h2o) No mitochondria: anaerobic so they don"t consume oxygen that they"re carrying. 4 heme groups each w/ fe in center (porphyrin) which can bind w/ 1 o2. Globin - 4 polypeptide chains (2 alpha + 2 beta) Have hb in rbc better than free in plasma b/c keeps hb from fragmenting + leaking + keeps hb from contributing directly to osmotic pressure + viscosity.