ANP 1105 Lecture Notes - Lecture 6: Central Chemoreceptors, Carbonic Anhydrase, Aortic Body

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Intrapulmonary pressure: = pressure within alveoli of lungs, rises & falls with breathing but always eventually equalizes with atmospheric. ~4 mm hg less than pressure in alveoli (less than atmospheric) always negative relative to. Deep/forced inspiration accessory muscles (neck & chest) raise ribs more; extend back by straightening spine (i) contract abdominal wall muscles: increase intra-abdominal pressure (ii) depress rib cage. 6. 5 explain the 3 factors that influence pulmonary ventilation. Neural influences: (i) parasympathetic (eg: inhaled irritants,histamine): constricts bronchioles also occurs during acute asthma attack (ii) sympathetic: dilates bronchioles: disease: eg: mucus, infectious material, solid tumours = sources of airway resistance. Very deep breaths stimulate type 11 cells to secrete more surfactant. Infant respiratory distress syndrome (irds): premature babies produce too little surfactant; alveoli must be re-inflated with every breath (positive pressure respirators, surfactant spray) 6. 5. 3 lung compliance: how much stretch and recoil is exhibited by the lungs: ease with which lungs can be distended.

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