BCH 2333 Lecture 8: February 7, 2017 - Supersecondary structure, tertiary and quaternary structure, protein folding
7 Feb 2017
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Combination of 2 o structure elements helices strands. Often repeated in the same protein; there is a pretty limited number of these at most, 100 different motifs made of secondary structural elements many are not that important, and do not show up that frequently. There are about 4 that make up the vast majority of what we see in this course (2 helices) hairpin. Helix-loop-helix dna binding or calcium binding. Helices are at 90 o to each other. Coiled coil cause the coils coil around each other. Useful for thinking about sequence and structure. Beta turn, driven by the hydrogen bond. Strand 1 and 2 interact and stabilize the antiparallel interaction. Very stable sheet interaction helix connects both ends of the strands together. Hydrogen bonds between strands are bent weaker. This is stabilized by helix hydrophobic binding surface. Quaternary structure describes the organization of subunits in a protein with multiple polypeptides. Oligomeric protein is more stable than dissociated subunits.
