BCH 2333 Lecture Notes - Lecture 17: Guanosine, Intron, Acid Dissociation Constant
8 May 2016
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Document Summary
Catalysis is similar to enzymes, it stabilizes the transition state. Ultimately the catalysts in biochemistry all work by stabilizing the transition state. It is composed of two structural domains with nucleotides from both domains contributing to the active site, which resides in a cleft between them: there are active site waters, which act as bases. 2 magnesiums are involved: charecterized by 5" phosphate. The virus recognizes t-cells, goes into the cell, and forms dna, and then incorporates the dna into the host genome. The cell makes the proteins needed for the virus. Drugable targets: (they all have approved drugs, it is usually a cocktail): reverse transcriptase, integration invent of viral rna into human cell, hiv protease. A lot off glycines in the flaps. They cleave the polypeptide chain to make the various prteins needed for the virus. There are two catalytic aspartic acid residues that project into the centre of the residues.
