BCH 3120 Lecture Notes - Lecture 11: Very Low-Density Lipoprotein, Pyrophosphate, Geranyl Pyrophosphate

• School: University of Ottawa
• Department: Biochemistry
• Course: BCH 3120
• Professor: Luc Poitras

Document Summary

Triacylglycerol (tag) synthesis: tissue fuel stores for average 70 kg human, triacylglycerol is good storage and good e. Fa can be attached to triacylglycerol and be stored in adipose tissue. In many cases, the limiting substrate during tag synthesis is the glycerol backbone: more precisely, tag synthesis begins with a molecule of glycerol-3-phosphate. Sources of glycerol-3-phosphate: recycling of the glycerol produced during b-oxidation of fatty acids, reduction of di-hydroxy acetone phosphate (dhap) produced during glycolysis, reduction of di-hydroxy acetone phosphate (dhap) produced during glyceroneogenesis, using gluconeogenesis to produce glycerol. Tag synthesis: biosynthesis in the liver, adipose tissues and intestine. Biosynthesis mostly occurs in liver: 2 pathways: contrast and compare, glycerol phosphate pathway = general, monoacylglycerol pathway = only used by intestine. Formation of dag in the intestine: can use same g3p pathway but can also use mag pathway: Starting point is not glycerol molecule but glycerol with already a fa attached: once you get triacylglycerol from diet