BCH 4122 Lecture 7: Lecture 7 and 8 notes SP1 as a molecular switch(1)
29 Mar 2018
School
Department
Course
Professor
Document Summary
On the role of the sp1 domain in hiv-1 particle assembly: a molecular switch: a. k. Datta, l. g. temeselew, r. m. crist, f. soheilian, a. kamata, j. mirro, d. Harvin, k. nagashima, p. e. cachau & a. Gag: role in immature hiv particle formation. Parts of gag (ma, ca, nc, sp1, sp2, p6. Structure of intact gag not solved but ma, ca (2 domains) and nc are. Ca domain plays important role in self-assembly of gag in immature virus formation. Lack of nucleic acid can be compensated by additional oligomerization domain . Sp1 seems to be important for gag self-assembly and particle formation. This paper is about sp1 and its role in protein-protein interaction in gag self-assembly. What is dielectric constant and why should it make a difference in protein folding. Less polar than water or acn, slightly more polar & more acidic than. Often used at low concentrations like tfe to enhance helix.
