BCH 4122 Lecture 5: Lecture 5 Notes_ Stiffness switch in HIV

• School: University of Ottawa
• Department: Biochemistry
• Course: BCH 4122
• Professor: Mary Hefford

Document Summary

Lecture 6 notes_(cid:862)a stiffness switch in human immunodeficiency virus . Nitzan kol, yu shi , marianna tsvitov, david barlam, roni z. shneck, michael s. kay et itay rousso, Like a number of viruses that infect animals, hiv has an envelope that is composed of the remnants of an infected cell. The complex of these two proteins is ofte(cid:374) referred to as (cid:862)e(cid:374)(cid:448)(cid:863) (cid:894)for e(cid:374)(cid:448)elope protei(cid:374)(cid:895). Gp (cid:1005)(cid:1006)(cid:1004) (cid:271)i(cid:374)ds cd(cid:1008) re(cid:272)eptors prese(cid:374)t on the surface of cells in the immune system with very high affinity. Only cells with the cd4 receptor on their surface. However the vast majority of cd4+ lymphocytes do display the cd4 receptor. In the interior of the hiv envelope, we find a matrix which is composed of multiple copies of a p17 (cid:894)ofte(cid:374) (cid:272)alled (cid:862)(cid:373)atri(cid:454) protei(cid:374)(cid:863), m,(cid:895) a(cid:374)d (cid:449)ithi(cid:374) this (cid:373)atri(cid:454), a (cid:272)apsid (cid:272)o(cid:373)posed (cid:373)ultiple (cid:272)opies (cid:894)~2000) of p24.