BIO 1140 Lecture Notes - Lecture 1: Mitophagy, Cell Damage, Atp Synthase
8 Nov 2016
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The hydrogen will dissipate when h+ diffuse back into the matrix. #1 a cell is unable to regulate its free intracellular calcium concentration and the plasma membrane begins to lose its integrity, becoming increasingly permeable to water and small ions. Most electrochemical gradients are disturbed or destroyed, which will likely lead to the cell"s death. Which type of cell death are you most likely witnessing: the cell is not going to die, necrosis, apoptosis, mitophagy, zombie attack. #2 the inner mitochondrial membrane is damaged and it becomes increasingly permeable to hydrogen ions. H+ still pumping into the inner mitochondrial membrane. No gradient, does not allow the rotation of the complexes and no atp production. H+ being pumped are not effectively used by atp synthase o make atp. Production of atp for every molecule of pyruvate that enters the mitochondrion is reduced. #3 draw a cell and explain how calcium is regulated. Opening of the ptp (permeability transition pore)
