BIO 1140 Lecture Notes - Lecture 17: Pyruvate Dehydrogenase, Electrochemical Gradient, Phosphate
15 Apr 2016
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Document Summary
Mitochondria are essential for many physiological biochemical functions: Metabolism (survival, growth) more than atp and processing nutrients. Response to stress oxidative, toxicity, drugs. Cell death active process need for proper organized cell death. Giving energy to one very large and important protein. Atpase runs in reverse hydrolyze atp or phosphorylate and convert atp into adp. Objective is to power it up and give it energy by using the concentration gradient of hydrogen ions. Causes it to rotate allows phosphorylation of adp to atp or opposite hydrolyze atp to adp and inorganic phosphate. The energy is in the phosphate bonds. Atpase enzyme proteins (all enzymes are proteins, except for ribosomes) 3,000 enzymes in the cell- all diferent (three part series of cellular respiration) goal is to make atp energy: glycolysis. Occurs in the cytosol - cytoplasm not in the mitochondria. End product pyruvate needs to be shuttled into mitochondria. Atp in -> 2atp + 2 nadh: krebs cycle.
