BIO 1140 Lecture Notes - Lecture 6: Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, Phospholipid
27 Feb 2017
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Document Summary
Membrane potential: the uneven distribution of ions creates potential energy: it can be measure in mv (millivolts, when channels open/close. Changing this ionic distribution, potential energy, and hence the membrane potential, changes: can lead to action potentials. Ion-channel-coupled receptors: they regulate the flow of ions across the cell membrane, different receptors regulate different ions, they are quite varied in shape, composed of multiple subunits that surround a central channel through while the ions flow. Tm receptors 1: ligand gated ion channels: very important for the nervous system used by many nts, some channels are specific to certain ions, others are less discerning, voltage-gated ion channels: are similar. They rely on change in voltage to open/close rather than ligand binding. Acetylcholine: ach is a very important neurotransmitter, can be excitatory or inhibitory (depending on receptor/cascade, can use 2 types of receptors (achr) (ionotropic or metabotropic): Gpcr"s (cid:894)(cid:373)uscari(cid:374)ic receptors(cid:895: ach ligand-gated ion channels:
