BIO 1140 Lecture Notes - Lecture 7: Signal Transduction, Homeostasis, Cytoskeleton
27 May 2016
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Document Summary
The mechanisms by which cells communicate are very conserved: physiology, cell growth, survival, cancer, hormonal regulation and homeostasis, development, immunity. Where is the message sent: the nature influences how it is relayed to the target cells, need a good message to get a good effect. Interpret the message, relay the message, set-up a response. Their structure will determine: their chemical properties (hydrophobic vs hydrophilic, the communication path taken to reach target cell, their mode of action / interaction with the cell and receptors. 6 classes: steroids, lipids, peptides / proteins, purines, amines, gases. Paracrine pathway: a signal that is sent to cells that are nearby. Autocrine: a signal sent to the same cell that it was sent from: used in a large cell that wants to act on a different region of that cell that is further away. Steroids: derived from cholesterol, lipophilic cannot be stored in vesicles (endocrine path)
