BIO 1140 Lecture Notes - Lecture 12: Acetylcholine, Hormone Response Element, Cortisol
Document Summary
By sending a chemical messenger that will trigger a signal transduction cascade. Regardless of the type of messenger, it must bind to a receptor. As long as the messenger is bound to the receptor, it keeps relaying that message. Can travel by autocrine, paracrine or endocrine pathways. Able to enter cell due to the fact that they are soluble to the membrane. When the complex that acts as the transcription factor finds its hormone response element, it initiates transcription on dna. Cortisol: when secreted by adrenal gland, travels around body in endocrine path and can get inside the cell to find its receptor because it is lipophilic. When bound to receptor, now a complex, which reaches the nucleus which can recognize a specific sequence (gre) and will commence transcription. Can also be used to shut off transcription. Response element is a sequence on the dna. Can be single protein or many different subunits together.