BIO 3102 Lecture Notes - Lecture 10: Tumor Suppressor Gene, Gene Duplication, Pseudogene
29 Aug 2016
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Need to find the rate of change orthologous genes in species 1 and 2 line up and score changes: 2. Ts (speciation time is known to solve for td), k = number of subs per site: 3. Introns are at same positions in the paralogous domains: can do dot matrix to compare domains, 1 2 is most similar; so most recent event. Phase limitations on exon shuffling: intron can be located within a codon, can lead to frameshift mutation. Do exons correspond to functional (or structural) domains at protein level: in some modern genes, especially multicellular organisms, has been used as argument for introns being very ancient, but now many examples of introns also located within domains. Evolution of new function (without duplication: 1. Is the intro in triplets: b) intron retained in final mrna, d) different transcription sites, f) mutually exclusive, g) cassette exon (exon skipping)
