BIO 3124 Lecture Notes - Lecture 14: Rna-Dependent Rna Polymerase, Hiv, Dna Virus
7 Dec 2016
School
Department
Course
Professor
Document Summary
Human papilloma, influenza and the human immunodeficiency virus. Type 6,11,16 and 18 are the most common. Penetration of enveloped virus in the nucleus a. Uses acquired envelope to get into nucleus by fusion of membrane. Envelope virus penetrates cell and acquires a second envelope. Segment is read, - to + rna is synthesized. Packs 1 of each of the 8 segments. Packages with each of 8 segments, viral rnap to generate orginal cell. Virus acquires envelope with spike proteins as it leaves. Have to use reverse transcriptase that is not provided by the cell. Composed of 2 proteins - gp 120 and gp 41. Allows integration of viral genome into cellular genome. 1 gene synthesizes into 1 protein which is cut into several proteins. There will be no entry due to endocytosis. Replication and integration of viral dna genome a. This dna will migrate to the nucleus and will be integrated into the host genome.
