BIO 3124 Lecture Notes - Lecture 4: Monomer, Idiotype, Vasodilation
25 Jan 2018
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November 3rd lecture (slide 454 slide 481) Involves a collection of serum proteins: complement proteins, c2, c3, c4, c5, c6, c7, c8 and c9, accessory proteins: b and p. Initiated by binding to components common to a great variety of bacterial cells: alternative: binding of c3b to lipid a or techoic acid. Opsonization: c3b and c4b, bacteria, viruses and parasites. Anaphylatoxins: c3a and c5a, activate granulocytes and monocytes. Membrane attack complex (mac: osmotic lysis, gram negative bacteria allows lysosome to reach cell wall, parasites loss of solutes. Neutrophil: phagocytic cell, high concentrations are indicative of an infection, normally absent in healthy tissues. Destruction of invading entity: phagocytosis, have receptors which recognize opsonins, enzymatic digestion, chemical destruction, antiseptics: peroxide and hypochlorite, release of granules. Inflammatory mediators: digestive enzymes, antiseptics: peroxide and hypochlorite. Recruit lymphocytes the third line of defense. Monocytes/macrophages/dendritic cells: phagocytes, have receptors which recognize opsonins, antigen presenting cells (apc)
