BIO 3124 Lecture 4: Micro Final Review 2
20 Dec 2018
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Generate particular proteins (autoinducers) that will be beneficial for the bacterial community. An autoinducer is a signalling molecule that is produced by the bacteria in response to changes in cell-population density. At a particular high concentration of these molecules, the bacteria is able to perceive its presence and change its gene expression. Autoinducers interact with one or more transcriptional regulators, and are therefore corepressors or coactivators of gene expression. Autoinducers could be used in clinical research to find ways to inhibit virulence or growth by disrupting cell communication or help quorum sensing in good bacteria. Gram-negative bacteria communicate mainly using n-acylated homoserine lactones. The length of the fatty acid chain will determine the specificity with which it binds to certain transcriptional regulators of certain species. Describe molecular mechanisms of quorum sensing in gram and gram + bacteria (use one example for each). Gram-negative using the lux system in v. fischeri.
