BIO 3153 Lecture Notes - Lecture 5: Neural Plate, Filopodia, Transmembrane Protein
23 Sep 2016
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Afs, mts, ifs, the other parts are the accessory proteins; they can mediate the dynamics of the 3 components. There are many proteins that can modify the dynamic of cytoskeletons. They help form higher order structures; mitotic spindle for example. There are a limited number of subunits, cell must regulate the use of subunits, and for example it must have enough tubulin. Slide 3: nucleation: important for producing the cytoskeleton. Microtubule is formed as ring, there is gamma tubulin protein complex that help with this. The gamma tubulin is found in mtoc (centrosome) in animal cells, and spindle pole body in yeast. The gamma tubulin forms gamma tubulin protein complex, this accelerates the microtubule formation. Nucleation occurs at the (-) end, therefore an a-tubulin binds to the gamma tubulin. Gamma tubulin is highly conserved; this means it"s the same in many species. Slide 4: nucleation can also happen in cytosol, typically in plants.
