BPS 1101 Lecture Notes - Lecture 7: Programmed Cell Death, P53, Apoptosis
28 Feb 2019
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Document Summary
Each tumor is unique, but the basic processes are similar (loss of control over cell division in organism) Apoptosis pathway doesn"t work in most cancer cases due to p53 being non-functional. Cells can only divide 50x in a lifetime. This is because the ends of our chromosomes have specialized tips (like shoelaces). Several mutations within the same cell are rare. Accumulation of mutations for cancer takes a period of time (avg 20+ years) Gene: set of instructions to make proteins (a,c,t,g: codon is 3 letters together that make a particular amino acid. Mutation: having the wrong code in one or more codons: think of it like a typo; this results in a change of aa, changing structure and function of the protein. This is the genetic basis for cancer: proto-oncogenes: genes involved normally in control of cell division, mutations from porto-oncogenes into oncogenes is a gene found in cancer.
