BPS 1101 Lecture Notes - Lecture 4: Coal Tar, Cytochrome C Oxidase Subunit Ii, Cyclooxygenase

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 1101
• Professor: William Ogilvie

Document Summary

Antikamnia: produced from coal tar, competing drug with aspirin. Acetaminophen: for visceral; raises your pain threshold, does not affect prostaglandins, does not deal with inflammation, p. ex: arthritis, weak stomach irritation, assigned as risk because of past drugs, creating a bad reputation regardless of evidence or not. In all bottle for safety: designed that the total amount of the drug in the package will not harm the child. Liver toxicity: liver chemically changes the drug to protect itself from poison (metabolizing, transferase removes the drug from the body. If the cytochrome enzyme turns to its active form, it becomes a toxic metabolite and cause liver damage. Tylenol and cyanide (1982: crazy person took out the powder from gelatine and replaced it with cyanide, worldwide recall from j&j. Implementation of more safety features were added to drugs. Anti-inflammatory classed-drug used to treat pain, fever and inflammation by blocking cyclooxygenase (active site) similarly to aspirin: motrin and advil are the same stuff.