BPS 2110 Lecture Notes - Lecture 11: Drug Design, Generic Drug, Reaction Rate Constant
7 Nov 2017
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De ne each concept from the provided list of key concepts. Refer to the rst-order model to derive the following equation: lnct = kt + inc0. Assess whether experimental concentration data measure over time are consistent or not with the rst- order model. Explain the underlying assumptions for the one compartment pk model. Explain the strengths of the physiological multi compartment model compared to the one compartment. Summarize the key pk parameters of water and explain an experimental procedure that could be used to assess the absorption, distribution, and metabolism of water within the human body. Explain how the relative and absolute bioavailability values are assessed. Resolve simple quantitative problems related to drug pharmacokinetics. Analyze and highlight important conclusions from a set of experimental data related to drug pharmacokinetics. Critical data analysis is essential to maximize invested research value. Cost for development of a new drug is ~ billion.
