BPS 2110 Lecture Notes - Lecture 15: Rectangular Function, Claudin, Cytoskeleton
7 Nov 2017
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Explain who, when, and how the impermeability of the bbb was rst established. Use a drawing to illustrate the molecular structure of the tight junction in brain endothelial cells. Identify three speci c proteins associated with the bbb. Identify two distinctive features of vascular endothelial cells and explain how each one affects the permeability of the bbb. List and explain the principle of four drug-deliver strategies that scientists have explored to improve drug delivery across the bbb. Explain the mechanism by which edta could increase the permeability of the bbb to drugs. 1880s: paul ehrlich observed that intravenous administration of dyes stained all organs except the brain and the spinal cord. 1913: edwin goldman demonstrated that the injection of the same dye into the cerebrospinal uid (csf) readily stained nervous tissue but not other tissues. Bbb as the interface between blood and the cns.
