BPS 4104 Lecture Notes - Lecture 5: Valine, Escherichia Coli, Percutaneous Nephrolithotomy
27 Mar 2018
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L5: amino acid and codon usage bias and indices. Ribosomes are expensive to make, cant make many. Understand how amino acid and codon usage biases affect translation efficiency and gene expression. Factors affecting amino acid and codon usage bias. Develop bioinformatic skills to study the genomic codon usage. Amino acid 1-letter code precursor metabolites energetic cost. 2 pep, eryp, prpp, _pyr 27. 7 eryp, 2 pep. Some are very rare aa"s, some are abundantly found in foods . Allows scientists to acknowledge which aa"s are impt in a seq. Prediction: usage of energetically expensive (and also rare) amino acids should decrease with gene expression. Large ~p/copy should be associated with small numcopy and small ~p/copy should be associated with large. Want to make a seq with abiundant aa"s so that the trna doesn"t take long to get the aa in the cytoplasm. Term = iso acceptor trna, group of trna that carries the same aas.
