HSS 2305 Lecture Notes - Lecture 45: Lipopolysaccharide, Tlr5, Flagellin

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Francois Cossette

Document Summary

Topics of human interest: type 1 diabetes, lupus (systemic lupus erythematosus sle, arthritis rheumatoid, transplant rejection. The immune system requires complex and highly specific interactions between many different types of cells and molecules. Many events must take place before a humoral or cell-mediated immune response can be initiated: this response makes these processes vulnerable to disruption at various stages by many factors. Various types of immune dysfunction are autoimmune diseases, which result when the body mounts an immune response against part of itself: more than 80 different autoimmune diseases have been characterized, affecting around 5% of the population. The specificity of the antigen receptors of both t and b cells is determined by a process of random gene rearrangement: me(cid:373)(cid:271)ers of these (cid:272)ell populatio(cid:374)s (cid:272)a(cid:374) ha(cid:448)e re(cid:272)eptors dire(cid:272)ted agai(cid:374)st the (cid:271)ody"s o(cid:449)(cid:374) protei(cid:374)s (self-antigens) Lymphocytes that bind self-antigens with high affinity tend to be removed from the lymphocyte population, making the immune system tolerant toward self.