HSS 1100 Lecture Notes - Lecture 2: Gastroenteritis, Tetanospasmin, Necrosis

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 1100
• Professor: Franco Pagotto

Document Summary

Contracted via contact with animal hydes and soil (enters via cutaneous and respiratory routes) The b. anthracis exotoxin is encoded on plasmid pxo1 (edema factor-disrupts water homeostasis, protecive anigen-promotes entry of edema factor to phagocyic cells, lethal factor-zinc metalloprotease that inacivates kinase) Plasmid pxo2 encodes the 3 genes required for synthesis of poly-glutamyl capsule **also needed for virulence** Anibioic will not alter course of symptoms if paient already has symptoms. Releases neurotoxin that blocks release of acetylcholine (ach) from nerve terminals in ans. Fatal food poisoning (from smokes ish or improperly home-canned vegetables. Infant botulism from fresh honey contaminated with spores (2-3 days consipaion, diiculty swallowing and muscle weakness) Puncture wound caused by object contaminated with spores. Releases tetanospasmin exotoxin, causes sustained contracion of skeletal muscle. Inacivated toxin vaccine available booster needed every 10 years. Causes gas gangrene (common in soldiers wounded in batle) Clostridial myonecrosis (pockets of gas in subcutaneous issues, may be fatal, necroic issue is removed)