HSS 1100 Lecture Notes - Lecture 4: Tuberculosis, Mantoux Test, Antimicrobial Resistance

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 1100
• Professor: Franco Pagotto

Document Summary

Contain high contents of lipids (wax) to be more resistant to disinfectants. Caused by inhalaion of aerosols that contain tubercle bacilli. Can survive in macrophages, allows them to spread in body. Primary complex= complex of local lesion in lung, draining lymphaics and enlarged lymph nodes. Even ater cell-mediated immunity stops infecion, bacteria may surviv in foci and reacivate in the future (relected in posiive tst) Late reacivaion of silent lesions in hosts with a certain degree of immunity. Cell-mediated most important, can be tested with mantoux test (doesn"t necessarily diagnose acive infecion) Examinaion of sputum smears, chest xray, cultures on special media. Someimes in paients with chronic pulmonary disease that is indisinguishable from tb. Show higher anibioic resistance, may give rise to doubful mantoux test. Causes peripheral nerve damage and enlargement and sensory loss. Mostly in developing areas, few cases in usa and canada. Mostly human to huan transmission (respiratory droplets) and may be from animals.