HSS 2305 Lecture Notes - Lecture 11: Helicase, Dna Replication, Dnab Helicase
12 Oct 2016
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October 12th: read chapter 13 section on prokaryotic cells, mitosis occurs in most of our cells, somatic ones, meiosis occurs in gamete cells (sperm and egg, conservative dna replication did not allow for mixing of parental and new. Dna polymerase iii is found in bacterial cells, they both work in the same direction because the lagging stranding is folded back on itself. Note, they still follow the rules in regards to which prime end they work towards. This is called the trombone model: polymerase cannot grab onto the template strand on its own, instead beta clamps grab onto the template to keep it in place and prevent the polymerase from falling off. The y clamp is used on the lagging strand and always has an open confirmation as the clamp has to actively open and close due to the. Dna being replicated in chunks on the lagging strand.
