HSS 2305 Lecture Notes - Lecture 3: Thermodynamic System, Equilibrium Constant, Digoxin

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Shannon Bainbridge

Document Summary

Enthalpy = total energy (h); decreases in spontaneous rxn. Entropy = measure of disorder of system (s); increase in spontaneous rxn. Decrease in t or s, decrease g. G<0 = exergonic, spontaneous; g>0 = endergonic, non spontaneous. Entropy allows molecules to bounce around, in turn allowing collisions leading to rxns. Equilibrium constant approaches infinity (e required to go back would be infinity) Taking adp, transfer back to atp to make e. Pumping of molecules or ions across membrane against c gradient. One third of all atp generated is used on na+/k+ atpase (pump) Helps maintain state of ca w/in heart, allowing it to pump. Cellular metabolism is at steady state, not equilibrium. Open thermodynamic system exchange of matter b/w system & surroundings. Forward rxn proceeds at same rate as reverse. Upon death, biochemical redistribute according to equilibrium. Some rxns might only go forward in certain parts of cell. Substrate binding site on enzyme designed to accommodate only specific substrate.