HSS 2305 Lecture Notes - Lecture 31: Inside Out Music, Cytoskeleton, Fibronectin

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Francois Cossette

Document Summary

D) laminin: general features, extracellular glycoproteins that consist of three different polypeptide chains linked by disulfide bonds; the molecule looks like a cross, 15 different types of laminin have been identified, functions: I(cid:374)flue(cid:374)(cid:272)e a (cid:272)ell"s pote(cid:374)tial for (cid:373)igratio(cid:374), growth a(cid:374)d differe(cid:374)tiatio(cid:374: example: Laminin allows migration of primordial germ cells, which arise in the yolk sac (located outside the embryo); these cells migrate by means of bloodstream and embryonic tissues to the developing gonads, where they form sperm and eggs. During their migration, primordial germ cells must go through laminin-rich surfaces: bind tightly to cell-surface receptors and to other laminin molecules, to proteoglycans, and to other components of basement membranes: In basement membranes, collagen molecules and laminin form a network responsible for strength and flexibility. In mouse, laminin would be essential to the formation of basement membranes. In space: fibrils can stretch as they are pulled on by cells and contract as tension is relieved.