HSS 3305 Lecture Notes - Lecture 12: Tumor Suppressor Gene, Benign Tumor, Vegf Receptor

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3305
• Professor: Karen Philips

Document Summary

1: reprogramming energy metabolism: changes in metabolism and mitosis to allow limitless proliferation, tumour-promoting inflammatory response: causes cell damage, evading immune destruction: does not allow the immune system to detect its foreign. In cancer, have mutation in ras, which is pathway that needs growth factor to activate it. With (cid:373)utatio(cid:374), do(cid:374)"t (cid:374)eed gro(cid:449)th fa(cid:272)tor, its per(cid:373)a(cid:374)e(cid:374)tl(cid:455) tur(cid:374)ed o(cid:374), u(cid:374)regulated (cid:272)ell proliferation. Malignant vs benign tumors: benign tumor cells grow only locally and cannot spread by invasion or metastasis, malignant cells invade neighboring tissues, enter blood vessels and metastasize to different sites. Cancer progression: cancer is process that takes time, starts by one cell, transformation -> initiation -> promotion -> progression, sometimes they create their own growth factors, change in genetic material prepares the cell to become cancerous. Genes and cancer: changes can happen due to genetics, environmental factors, free radicals, viruses, radiation, chemicals, causes stress on cells to go through proliferation.