MED 1201 Lecture Notes - High-Performance Liquid Chromatography, Dilated Cardiomyopathy, Creatine Kinase
20 Nov 2012
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Foundations unit cbl2 duchenne muscular dystrophy. Objectives: describe the chemical nature, structure (primary, secondary, tertiary and quaternary), and properties of proteins using myosin and actin as examples. For myosin, it"s head, neck and tail. Tertiary the 3d structure of each subunit. Quaternary protein complexes combining together to make one unit: recognize how different types of gene mutations result in abnormal protein. For actin = multimer (actin proteins coming together to make microtubules) For myosin, it"s a dimer production: describe the relevant and appropriate history, physical examination, diagnostic tools and investigations for a patient with a myopathy/muscular dystrophy. Progressive symmetric muscular weakness (proximal greater than distal) often with calf hypertrophy. Progressive symmetric muscle weakness and atrophy (proximal greater than distal) often with calf hypertrophy; weakness of quadriceps femoris may be the only sign. Flexion contractures of the elbows (if present, late in the course) Wheelchair dependency (if present, after age 16 years)
