PHS 1200 Lecture Notes - Lecture 4: Respiratory Alkalosis, Respiratory Acidosis, Metabolic Alkalosis
9 Feb 2017
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Ph<7. 35 = acidosis; >7. 45= alkalosis ph depends upon bicarb present in the kidnet divided by the co2 that exists in the lungs. Base kidneys either recycle or produce more bicard which constributes to ph. Acid driven by the lungs (gas exchange) co2 in the blood exists in gas form and solution (it dissolves) If the ratio of bicarbonate: carbonic acid remains 20:1, the ph will be 7. 40. Pco2 x solubility in water = moles of carbonic acid. If carbonic acid increases then bicarb must increase to maintain normal ph. A decrease in ph ie. acidosis stimulates hco3 production. Renal compensation in response to a change in ph takes severs days- a week to reach the full response. The lungs regulate ph by altering pcos excretion. A decrease in ph i. e. acidosis stimulates ventilation to drop pco2. An increase in ph i. e. alkalosis decreases ventilation to raise pco2. Respiratory compensation in response to a change in ph are immedicate.
