PSY 3142 Lecture Notes - Lecture 5: Catabolism, Reserpine, Antipsychotic

• School: University of Ottawa
• Department: Psychology
• Course: PSY 3142
• Professor: Philip Wall

Document Summary

They are grouped together because the possess a single amine group (monoamines). All are synthesized by tyrosine in metabolic steps each controlled by a different enzyme. Presence or absence of a certain type of catecholamine is determined by the enzymes which are present. Tyrosine hydroxyls adds a hydraoxyl (oh) group to tyrosine to create l-dopa. Tyrosine hydroxyls is the rate limiting enzyme. This is the precursor to all three catecholamines. L-aminoacid decarboxylase is added to l-dopa to create dopamine. Pathway: begins in the ventral tegmentum area: mesolimbicortical pathway: ventral tegmental area to the nucleus accumbens, cortex, and hippocampus. Originates in the midbrain and projects to the limbic system: mesostraiatal pathway: substance nigra to the stratum, caudate and putamen. Originates in the substantia nigra in the midbrain to in uence the caudate nucleus and putamen. Plays a role in motor control, damage leads to incoordination or. Dopamine is also seen to be a part of reward, motivation, and movement.