PSY 4327 Lecture Notes - Lecture 4: Non-Rapid Eye Movement Sleep, Orexin, Delta Wave
12 Nov 2017
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Sleep is an active process: 1916: brainstem first identified as necessary for normal sleep-wake regulation, sleeping sickness (encephalitis lethargica) or von economo disease, caused by viral encephalitis. Lecture 4: the brain in sleep from the spanish flue. International influenza pandemic from 1915- 1926, wwi spread it around the world. Secondary bacterial pneumonia was also a huge factor. Sleep is an active process: many of those who survived never returned to their pre-existing aliveness. Neuroanatomy of sleep: moruzzi and magoun, 1949, named the aras (ascending reticular activating system, more recently, ascending activating system (aas) If pons was stimulated, would lead to eeg typical of wakefulness: later shown lesions and infracts= coma, conclusions, sleep-wake center of the midbrain, aras stimulates the cortex. Jouvet, 1962, 1984: lesions studies in the brain stem, upper locus coeruleus = motor inhibition of rems, median locus coeruleus = cortical activations of rems (2 separate systems) Independent: you can have one and not the other (e. g. rbd)
