BIO200H5 Lecture Notes - Lecture 14: Red Blood Cell, Drug Metabolism, Methyl Group
Document Summary
Acetyl coenzyme a i the cofactor (molecule that helps enzyme work. Another example of a coenzyme is nadph in phase i) works by adding acetyl group to an amine part of a benzene ring: ex; not enough serotonin can lead to depressive symptoms. The benzne- like structure on serotonin gets acetylated by nat, which deactivates the drug molecule. Glucuronidation can also occur on the alcohol or amine, as well as sulfation on the alcohol or amine as well. Transfers methyl group (sam) to a nucleophile on the drug (ex; an alcohol, amine). It will pick of the methyl group and you"ll end up with a de-methylated. A summary of phase ii drugs, including the enzyme involved, donor, and metabolite can be seen on slide 5 of lec 14** Note: phase ii reactions occur more quickly than phase i because they"re transferring molecules that are already activated onto the drug. Whereas, in phase i reactions need priming, and get activated.
