BIO373H5 Lecture Notes - Lecture 18: General Idea, Common Source, Antimicrobial Resistance
Document Summary
Tetanus lock jaw; spastic paralysis, extreme muscle contractions. Pathogenicity ability to cause disease; qualitative measure. Not all organisms have the same level of virulence, Toxicity: exotoxin tetanus produced for the cause of symptoms; the bacteria itself does not reproduce and spread throughout the body but just the toxin spreads and causes symptoms. Invasiveness : invade host tissues and colonize and inhibit host function, Streptococcus strain which causes pneumonia sometimes have capsules which prevents phagocytosis which prevents wbcs from being able to get rid of any toxin producing parts of the invader. Adhesion factors: pathogens use this to adhere to epithelial lining so that it becomes difficult to flush them out. Extracellular enzymes: affect the cell to cell adhesion. Toxins: spread and inhibit host function by causing specific symptoms. Some might not be virulent but on contact with other virulent salmonella cells have easily initiate into invasiveness. Certain proteins and other factors which cause this phenomenon.
