BIO380H5 Lecture Notes - Lecture 28: Tgf Beta 1, Bronchus, Fibroblast Growth Factor Receptor 2

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23 Nov 2016
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Bio 380 lecture 28 respiratory system. The lungs continue to develop after birth until age 8. At the terminal of the bronchioles there are the respiratory alveoli cells. The alveoli cells will form the lung tissues. On the right side of the body there are three secondary bronchi and two on the left because of the position of the heart. Fgf 10 will induce fgfr-2, these two will inhibit nkx. 2. 1; at this point the trachea will stop elongating and will indicate the site of division. Shh and tgf beta 1 will inhibit the expression of fgf. Tgf beta 1 will induce the formation of fibrous tissue (fibronectin, collagen i, iii, Iv); there will be no further movement at this point. Bmp -4 will be expressed at the site of division, and fgf. 10 will move unto the other sides of the trachea and will elongate to form the new bronchus.

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