BIO200H5 Lecture Notes - Lecture 4: Glycocalyx, Area Postrema, Neostigmine
Document Summary
Absorption i: the cell and its barriers: introductory, general plan of coming lectures, first big topic: absorption . A: barriers: cellular (today), whole body (next lecture) Review: plasma membrane: membrane composition, membrane structure unstirred h2o glycocalyx phospholipid bilayer with proteins cytoplasm, function of the membrane components phospholipids proteins, action of drugs on the membrane phospholipids proteins. Absorption ii: the body and its barriers: review: body structure. Review: body walls - general occluding zonulae macule junctions. Note: there are two important barriers to drug molecules: the epithelium and the blood-brain barrier. External walls epithelial barrier: skin general (occluding zonulae) Note: includes cornea of eyes, linings of lungs, lining of bladder: gastrointestinal (occluding zonulae) enzyme barriers. Internal walls: cell membranes (divide intra- and extra-cellular space) Q: why is this barrier needed? (not important for drug molecules: capillary walls in general (no barrier) (no barrier for drug molecules, except those bound to plasma proteins)