BIO200H5 Lecture Notes - Lecture 9: Aspirin, Asthma, Clearance Rate
Document Summary
Ways drugs can permeate into the cell aqueous, lipid, special carrier, endo/exocytosis . The drug is present in the intestinal lumen and we want it to go from intersistium and eventually to cardiovascular system. Factors affecting drug permeation across any plasma membrane: partition coefficient. Tells us how readily the drug can move between both types of environments. We can describe the ability to move thru the environment thru p, or log p. [compound]water log p = log (cid:894)[compound]octanol(cid:895) log (cid:894)[compound]water(cid:895) We can"t have free phospholipid hanging around, we use octanol. Then we calculate how much stays in octanol layer vs how much stays in lipid bilayer. This tells us an increase in log p means your lipid is more lipid soluble. Because water is a polar molecule, it forms a shell around what"s positively charged and what"s negatively charged. That"s why salt dissolves when you add it to water when you cook something.
