BIO342H5 Lecture Notes - Lecture 22: Transfer Rna, Anthocyanin, Glutamine
Document Summary
Protein coded sequence: left to right, 5" to 3". Introgenic regions on outside, on inside it is introns. Nucleotide rna trna ribosome amino acide fold to form 3d structure. Mutation at third site almost never changes a. a. , but 1st and second does. If we change that codon sequence so it is no longer glutamine- non- synonymous substitution. Changing second to c then you have alanine- chemical properties are different. They have different chemical and biochemical properties then that can effect function a lot. So for eg the chalcome synthase- core can be severely effected. Structural mutations change the structure, thus function of protein. If we change when and where it is turned on or the amount of expression. Cis-regulatory- part of dna that is upstream, short seq of non coding dna to initite translation of protein, or transcription factors can lead to regulatory mutations. We can have structural mutation in dfr. Or we have regulatory mutation, down-regulate f3"h.
