PSY397H5 Lecture Notes - Lecture 10: Creb, Protein Synthesis Inhibitor, Rna Polymerase Ii
Document Summary
Creb (cyclic amp response element binding protein) is a transcription factor that is important in late phase ltp because it triggers the expression of most genes involved in making proteins for synapses. If the gene is knocked out, it cannot initiate gene expression: you can inhibit late phase ltp therefore by taking out creb kos. Arc antisense: arc is a transcription factor that initiates gene expression. If arc is removed, it acts as a protein synthesis inhibitor. It also inhibits late phase ltp if inhibited. The last type of experiment is called mimic experiment which mimics a biochemical process during ltp production: the creb protein is produced inn costitutively active form. If you replace the original creb gene with a different mutated form that causes creb to be constantly active, thus leading to increase in l-ltp induction (this is the mimic component-(cid:449)here the (cid:373)utated for(cid:373) (cid:373)i(cid:373)i(cid:272)"s creb) Creb binds to a camp response element.
