BIOA01H3 Lecture Notes - Lecture 29: Mendelian Inheritance, Sickle-Cell Disease, Zygosity

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12 Jun 2016
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Most traits in humans are due to the interaction of multiple genes and do not show a simple mendelian pattern of inheritance. A few traits represent single-genes: e. g. sickle-cell anemia, cystic fibrosis, tay-sachs disease, huntington"s disease. Because we cannot do breeding experiments on humans, we must use pedigrees to study inheritance. We do family trees and follow the characteristics traits through generations and try to deduce information. Pedigrees are an orderly diagram of a families relevant genetic features extending through multiple generations. Pedigrees help us infer (deduce) if a trait is from a single gene and if the trait is dominant or recessive. Allow inferences concerning genotypes and predictions concerning phenotypes of offspring (genetic counseling). We can predict certain probabilities of genotypes and phenotypes from pedigrees. The first 22 pairs of chromosomes are autosomes and the pair number 23 is the sex determinant chromosome. A picture of chromosomes of a person is called a caryotype.

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