BIOB10H3 Lecture Notes - Lecture 7: Mitochondrion, Mitochondrial Fusion, Mitochondrial Matrix
Document Summary
Mitochondria: structure &function: mitochondria arose from aerobic prokaryotes, mitochondria can divide within the cell = mitochondrial fission = binary fission, mitochondria also fuse within the cell = mitochondrial fusion, balance between fission and fusion dictates mitochondrial number and length. Inner membrane (cristae) (imm: outer membrane (omm, matrix, mitochondria have 2 membranes & 2 aqueous compartments. Inbetween the the omm and the imm is the intermembrane space. Answer: the presence of ribosome"s and atp synthase molecules. The chromophour in the centre is similar to the way the ligand in a porin sits. Q: cardiolipin is found on the imm and many bacterial membranes. Matrix proteins: signal = mitochondrial presequence , at the n-terminus of proteins: composed of several positively charged residues. Imm proteins (integral membrane proteins): contain internal targeting sequences (poorly defined) we don"t really know much about it stop-transfer sequences that allow it to be embedded in the membrane.
