BIOB32H3 Lecture Notes - Lecture 4: Saltatory Conduction, Voltage Clamp, Axon Terminal
5 Nov 2017
School
Department
Course
Professor
Document Summary
The action potential ii: the refractory periods of the action potential, coding of stimulus intensity, conduction of the action potential down the axon, multiple sclerosis. Spontaneous graded potentials and action potentials are decreased in the striatum in. In 1971 luigi galvani discovered that electrical signals from lightening or primitive batteries could cause contraction of the leg of an otherwise dead frog. Lead to studies on the heads of hanged criminals attempting to bring back the dead: using his instrument called the differential rheotome in 1871 julius berstein first described an action potential as negative variation. Time course independent of stimulus: action potential almost complete before muscle contraction. In 1949 hodgkin and katz rediscovered negative variation / the overshoot. Explained transient reversal in resting membrane potential by influx of na+ In 1952 hodgkin and huxley worked out the ionic basis of the action potential and developed a mathematical model that successfully predicted the speed of propagation in the squid giant axon.
