BIOB33H3 Lecture Notes - Thyrotropin-Releasing Hormone, Corticotropin-Releasing Hormone, Anterior Pituitary

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20 Mar 2013
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General functions: regulate metabolism, h2o and electrolyte balance, coping with stress, growth and development, reproduction, rbc production, digestion/absorption. Most hormone systems operate with negative feedback. Diurnal (circadian) rhythms: hormone secretion varies throughout time (a day-days-months, set point changed by cns, negative feedback maintains level at set point for that time, external cues like light/dark or activity/inactivity. Endocrine disorders: hyposecretion (genetic, dietary, toxins, immune disorder, hypersecretion (tumors, abnormality of target cell (lack of receptors or lack of enzymes for reactions) Melatonin: regulates biological clock, cued by light/dark sensed by eyes, may also, induce sleep, inhibit sex hormones, enhance immunity, slow aging (antioxidant, hypothalamus and posterior pituitary (neurohypophysis) Hypothalamus produces hormones that are stored in posterior pituitary: hypothalamus signals release with aps. Vasopressin (adh: conserves h2o (when osmolarity increased, vasoconstrictor (when ecf/bp decreased) Oxytocin: uterine contractions during childbirth, estrogen has permissive effects, triggered by neuroendocrine reflexes (baby"s head pushing against cervix, milk ejection, triggered by baby nursing, hypothalamus and anterior pituitary (adenohypophysis)

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