BIOC13H3 Lecture Notes - Lecture 9: Glucokinase, Endergonic Reaction, Phosphorylase
Document Summary
Colligative, depends only on the concentration, and not the identity of the molecule. The more glucose you have in the cell, the more age you get forming and these age. It can react with proteins to lead to age are non-enzymatic so they cant be regulated. Age are not good, they tend to cause negative clinical outcomes. They can be eliminated by detoxification and renal elimination (urine) Age are related to nephropathy, neuropathy, retinopathy. Hemoglobin a1c is a glucose bound to hemoglobin. This alters the hemoglobin"s affinity for oxygen. Patients with high a1c levels, the saturation is shifted up, meaning less oxygen is being released by hemoglobin and delivered to tissue. It becomes harder for the blood to offload oxygen to the tissues. One of the solutions bird have to prevent high glucose from causing problems, the birds have less glycated hemoglobin. In some way the hemoglobin protein in birds is far more resistant to binding with hemoglobin.
