BIOC13H3 Lecture Notes - Lecture 12: Pyruvate Dehydrogenase Complex, Acetyl-Coa, Pdk4

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17 Apr 2017
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Third step is to transfer thioester to coa from lipoic acid. Then you create acetyl coa, near equilibrium reaction because the energetics released is used to synthesize acetyl coa. Last 2 reactions are simply oxidation reactions, they serve to oxidize lipoic acid. Fad is similar to nad, can accept electrons from lipoic acid and becomes fadh2. Then nad comes in and steals electrons from fadh2. Electrons of pyruvate have made their way to nadh and carbons of pyruvate have ended up as co2. About 24-30 that form the outside of the compound. Then inside have 60 copies of e2 enzyme in center. Allows for substrate channeling when they are all sitting together. If they were separate enzymes then e1 does its reaction, produces intermediate, then that will have to diffuse and find the next enzyme and so on. Disadvantage is that the intermediates might get lost along the way.

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