BIOC15H3 Lecture Notes - Lecture 12: Robertsonian Translocation, Ras Subfamily, Tumor Suppressor Gene

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18 Nov 2013
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Bioc15fall2013 lecture 12 notes: chromosome mutations and cancer and lecture 13 notes: cancer and deletion mapping: using chromosome mutations. Inversion 180 degree rotation of a chromosomal region. Non-reciprocal unequal exchanged between non homologous chromosomes. Reciprocal parts of 2 non homologous chromosome trade places: deletion removal of a segment of dna, transposition movement of short dna segments from one position in the genome to another. Increased rate of chromosomal aberrations broken chromosomes, multiple copies of chromosomes, deletions of large chromosomal segments or a whole chromosome fidelity of chromosome reproduction is decreased in tumour cells. Deletions the loss of a segment within one chromosome and the juxtaposition of the two segments on either side of the deleted segment: ex: cri du chat syndrome. In(i) = inversion in chromosome 1: duplication -> dp(3l) = duplication in left arm of chromosome 3, t(3r) = translocation in the right arm of chromosome 3, df(3r) = deficiency in the right arm of chromosome 3.

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