BIOC19H3 Lecture Notes - Lecture 11: Peanut Butter, Nanoshell, Immunotherapy

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grayhare730

20 Feb 2013

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This leads to the development of cancer and abnormal development. This is abnormal development and the cells are dividing when they should not. Cancer can occur in virtually any cell type. However, it is more frequent in some cell types than others. Within a cancer, patients can show variations in the symptoms. There is a loss of control of cell division. These are cells that are dividing when they should not. This is when they are migrating to other tissues when they should not. The cover slide shows cancer cells growing in tissue culture. On the bottom of the dish they are sending out trails that are invading into other cells. Studies were needed to determine what goes wrong in cancer cells. To understand we needed to understand what happens in a normal cell in relation to division. A normal cell is undergoing a controlled rate of cell division.

Related Questions

Given the scenario/situation, respond to all questions with complete sentences.

Scientists have been studying the effects of Starkagaren Disease, which is regulated by the stgn gene, in cultured normal and breast cancer cell lines. They have fused a yellow fluorescent probe to the end of the stgn gene to study the disease more closely. By adding a probe, it will create a hybrid protein that emits a yellow color under a blue laser. This hybrid protein is known as a fluorescentâtagged protein, meaning that the protein itself will function and fold normally but it will be tagged with a yellow fluorescent probe (YFP) at the end. This allows the scientists to follow the protein through the cell cycle. They find that the stgn protein normally binds to centromeres in normal cells. After looking at cells at various stages of the cell cycle, they find that compared to normal cells, the breast cancer cells that express the Starkagaren Disease display abnormal nuclei, some appear very large, some have tiny nuclei, and some cells do not have a nucleus at all.

a) Because the STGN protein binds to the centromere, the scientists can also study what other structure?

b) After looking the defects of the affected cells, where in the cell cycle would you guess the error occurs? What do you think happens?

c) The stgn gene appears to not be functioning, do you think the scientists are able to see the STGN protein at the centromeres? Why?

d) The scientists want to see what would happen if they could block the stgn gene from being made in normal cells or lung cancer cells, what is one way they could do this?

rosecockroach918

{Reposted Question} Given the scenario/situation, respond to all questions with complete sentences.

Scientists have been studying the effects of Starkagaren Disease, which is regulated by the stgn gene, in cultured normal and breast cancer cell lines. They have fused a yellow fluorescent probe to the end of thestgn gene to study the disease more closely. By adding a probe, it will create a hybrid protein that emits a yellow color under a blue laser. This hybrid protein is known as a fluorescentâtagged protein, meaning that the protein itself will function and fold normally but it will be tagged with a yellow fluorescent probe (YFP) at the end. This allows the scientists to follow the protein through the cell cycle. They find that the stgn protein normally binds to centromeres in normal cells. After looking at cells at various stages of the cell cycle, they find that compared to normal cells, the breast cancer cells that express the Starkagaren Disease display abnormal nuclei, some appear very large, some have tiny nuclei, and some cells do not have a nucleus at all.

a) Because the STGN protein binds to the centromere, the scientists can also study what other structure?

b) After looking the defects of the affected cells, where in the cell cycle would you guess the error occurs? What do you think happens?

c) The stgn gene appears to not be functioning, do you think the scientists are able to see the STGN protein at the centromeres? Why?

d) The scientists want to see what would happen if they could block the stgn gene from being made in normal cells or lung cancer cells, what is one way they could do this?

copperferret659

In referring to the war on cancer, J. Michael Bishop, a Nobellaureate for
his work with oncogenes quoted a line from the Pogo comic strip:âWe have
met the enemy and he is us.â Why is this quotationappropriate?

Normal cells greatly slow their rates of cell division afterfilling a culture
dish with a layer one cell deep (a monolayer). If a circular groupof cells is
removed from the middle of the filled culture dish, the cells onthe edges of
the "wound" will begin to divide, fill the space and then stopdividing again.
How does the behavior of transformed cells differ?

You are studying a gene that is involved in the development oftumors.
The gene is represented once in the affected cells. The allele ofthe same
gene on the homologous chromosome is normal. When the gene isinserted
into normal cells, the cells are transformed. What type of gene isthis?

goldcrocodile14

BIOC19H3 Lecture Notes - Lecture 11: Peanut Butter, Nanoshell, Immunotherapy

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