BIOC34H3 Lecture Notes - Lecture 19: Parathyroid Gland, Homeostasis, Thyroid

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!"#$%&'()*+,-.*(/0( ( 12345(
Mar.%7,%2018%
76%
Calcium(&(Glucose(Regulation(and(
Clearance!
Calcium(Regulation(
• Want%to%maintain%a%level%of%calcium%in%the%plasma%
o When%too%low,%reabsorb%Ca%from%the%bone%
o When%too%high,%deposit%Ca%into%the%bone%
o Absorb%Ca%from%digested%food%in%the%got%
o Can%also%reabsorb%or%filter%more%Ca%from%the%kidneys%
• Three%hormones%involved%in%blood%calcium%levels%(BCL)%
o Parathyroid%hormone%for%raising%BCL%
o Calcitrol%for%raising%BCL%
o Calcitonin%involved%in%decreasing%BCL%
Thyroid(and(Parathyroid(Glands(
• Thyroid%and%parathyroid%
glands%are%in%the%neck%
• Thyroid%produces%
+45+2,6323%when%BCL%are%
too%high%
• Parathyroid%gland%process%
74.4,89.62:(86.;63*(
<=>?@%when%BCL%is%too%low%
• When%BCL%rises%too%high,%
thyroid%gland%releases%
calcitonin%
o Decreased%uptake%of%
Ca%
o Ca%is%deposited%into%
the%bones%
o Causes%a%decrease%in%BCL%back%to%normal%
• When%BCL%fall%too%low,%parathyroid%glands%produce%PTH%which%stimulates%
the%reabsorption%of%Ca%from%the%kidneys%and%the%release%of%Ca%from%the%
bones%
o Causes%an%increase%in%BCL%
o Calcitrol%is%also%produced%for%increase%Ca%uptake%from%the%gut%%
Calcitrol(
• Cholesterol%is%converted%into%A2,4;23(B%(by%the%sunlight%and%then%25-HOD3%
in%the%liver%
• When%BCL%is%low,%the%25-HOD3%is%converted%into%+45+2,.65%due%to%PTH%
stimulation%of%the%kidneys%
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